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Nerve Injuries Carpal metacarpal arthritis is arthritis at the base of the thumb joint. In a normal joint, cartilage covers the ends of each bone providing smooth and. From joint inflammation to compressed nerves, problems that may be to blame for painful hands and wrists. Many forms of arthritis and related conditions that affect the joints, muscles and/or bones can cause problems like pain, stiffness and swelling in the wrist and fingers.